Distinguishing between Genomic Regions Bound by Paralogous Transcription Factors
نویسندگان
چکیده
Since it is not possible to compute E-scores for 10-mers from PBM data, we used 10-mer pseudo-intensities to perform an analysis similar to the one described in the main text for 8-mer E-scores. We estimated the 10-mers intensities from the 7-mer and 8-mer median intensities. Let X = X1X2 . . . Xk be a DNA site of length k, with Ik(X) it’s median intensity, and Ek(X) it’s energy. Then the intensities for all 10-mers are computed in the following steps: compute all 7-mers and 8-mers energies from 7-mers and 8-mers intensities (Eq. 1); compute all 10-mers pseudo-energies using additions and subtractions (Eq. 2); from pseudo-energies, compute all 10-mers pseudo-intensities (Eq. 3).
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